Precision medicine is an approach that takes into account individual variability in genes, environment, and lifestyle to identify clinical phenotypes that would benefit from targeted and highly effective therapies. Given the growing advances in our understanding of the pathobiology and management of pulmonary vascular disorders such as pulmonary arterial hypertension (PAH), pulmonary embolism (PE) and chronic thromboembolic pulmonary hypertension (CTEPH), the time is ripe to discuss how a precision medicine strategy could help facilitate the translation of scientific discoveries into clinical tools that can help improve our capacity to properly identify the optimal treatment strategy for these patients.