There are several advances in cystic fibrosis care that have led to major demographic changes. There are now more adults than children with CF in the Unites States. We now have medications that address the underlying defect in more than half of CF patients, with ongoing clinical trials to address the majority of other patients. This session will update the audience on CF epidemiology, pathophysiology and treatments, and highlight key updates in CF care and management in a case-based format.