A comprehensive and up to date review coupled with interactive tumor boards will cover screening and development of screening programs, tobacco interventions, prognostic factors, and approach to pulmonary nodules (solid and sub-solid) including nodule management guidelines and diagnostic interventions. In addition, we will discuss challenges in SBRT for Stage I: when is it clinically indicated without tissue confirmation and a pro con debate on whether all patients need to undergo EBUS for nodal staging, the epidemic of lung cancer in women, advances in personalized medicine and immunotherapy, management of malignant pleural effusions and toxicities due to lung cancer therapies.