Necroptosis is a form of regulated cell death that results in the release of immunomodulatory DAMPs. Although mounting evidence suggests a critical role for necroptosis in the development of vascular disease, promotion of the tumor microenvironment and host-pathogen interactions, the importance of necroptosis in lung diseases is only beginning to be understood. This symposium will provide attendees with a basic understanding of necroptosis and its emerging role in the pathogenesis of lung diseases including COPD, ARDS and Pneumonia. Additionally, the interplay between necroptosis and other cell death pathways and the clinical use of necroptosis biomarkers will be examined.