The developmental origins of health and disease theory is based on evidence that a suboptimal environment during fetal and neonatal development can impact the evolution of adult-onset disease. A compromised prenatal (and early postnatal) environment leads to increased risk of a number of chronic diseases. DOHaD research is only just emerging as a significant force with respect to lung health and disease. This session will highlight fundamental elements of the DOHaD theory, leveraging examples of significant advances in other disease areas, as well as presenting current significant advances being made with respect to an array of lung disorders.