The NIH-supported Environmental Influences on Child Health Outcomes (ECHO) program supports multiple, synergistic, longitudinal studies using existing cohort populations to investigate influences of environmental exposures (physical, chemical, biological, social, behavioral, natural and built environments) on child health and development, including respiratory outcomes. The multiple cohorts will share standardized core data elements from about 50,000 children. These core elements will include analyses through the Children's Health Exposure Analysis Resource (CHEAR), Patient/Person (parent and child) Reported Outcomes (PROs), and genetics. This session will focus on evidence of developmental origins of health and disease, the design of ECHO, and how researchers can leverage ECHO.