Event

The purpose of the ALA-ACRC is to conduct clinical trials with practical importance to adults and children with asthma and COPD. ACRC has produced manuscripts from data analyzed from the LASST, MICT, SCS, and REACH trials. For the LASST trial, the primary hypothesis was that stopping LABA would be inferior to reducing ICS dose and continuing LABA; the secondary hypothesis was that reduced ICS/LABA would be non-inferior to stable ICS/LABA. The primary outcome was time to treatment failure. The MICT trial hypothesized that incorporation of mobile devices and the internet into a study design that tests interventions to reduce morbidity in pediatric asthma would result in a lower-cost method for conducting a clinical trial and encourage more families to participate. The SCS trial was designed to evaluate the performance characteristics of study questionnaires (ACT and ASUI) and composite measures of asthma control (EPAC and TRS) for people with asthma who are active smokers. The objective of the REACH trial was to systematically characterize a diverse cohort of children with airflow obstruction resistant to BD.