Airway microbes determine many aspects of asthma, including risk factors for asthma development, asthma exacerbations, and disease persistence and severity. The NIH-sponsored Inner City Asthma Consortium has gained insight into the roles of environmental microbes, respiratory viruses and bacteria, as factors in asthma development and the relationship and contribution to asthma exacerbations. This session will allow attendees to understand the role of the microbiome as a risk for asthma and the effects of respiratory viruses on the airway microbiome in relation to asthma exacerbations; and the transcriptomic pathways associated with respiratory infections and exacerbations.