Climate change has been described by the Lancet Commission as “the greatest public health opportunity of the 21st Century.” This scientific symposium will objectively examine this opportunity with a focus on cardio-pulmonary health and public policy. The symposium will open with the perspective of a physician from Cameroon discussing the effects of climate change on the health of people in Africa. A series of speakers will review evidence of cardio-pulmonary health effects of greenhouse gas emissions and climate change, and identify vulnerable populations. Finally, a former EPA administrator and U.S. Senator will discuss challenges and opportunities of the 2015 Paris Climate Agreement for physicians, scientists and patients.